Beilstein J. Org. Chem.2019,15, 357–363, doi:10.3762/bjoc.15.31
crucial for the intramolecular cyclopropanation reaction in a water/ether biphasic medium. The water-soluble catalyst could be reused at least six times with little loss in yield and enantioselectivity.
Keywords: asymmetric synthesis; carbene transfer; cyclopropanation; diazoester; intramolecular
diazoamide; Ru(II)-Pheox; water-soluble catalyst; Weinreb amide; Introduction
Water-soluble transition metal complexes have been attracting increasing interest for catalytic applications because of their many advantages such as simple product separation, low cost, safety, and environmentally friendly
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Graphical Abstract
Figure 1:
A comparison of the solubility of Ru(II)-Pheox (cat. 1) and Ru(II)-Amm-Pheox (cat. 2).